EPS secretion

We combine cryo-EM, X-ray crystallography, imaging, biophysical and biochemical assays, molecular biology and classical bacteriology to study the structural determinants of exopolysaccharide secretion in bacterial biofilms.

c-di-GMP signaling

We are interested in the mechanisms of c-di-GMP signal transduction and its inverse effects on flagellar motility and biofilm formation.


Krasteva @ & Sondermann @, Nature Chemical Biology 2017

Matsuyama*, Krasteva* et al., PNAS 2016